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KMID : 1140420170260030188
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Journal of Obesity & Metabolic Syndrome
2017 Volume.26 No. 3 p.188 ~ p.196
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Association between Serum Dipeptidyl Peptidase-4 Concentration and Obesity-related Factors in Health Screen Examinees
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Lee Ji-Yeon
Jang Byoung-Kuk
Song Min-Kyung
Kim Hye-Soon
Kim Mi-Kyung
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Abstract
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Background: Dipeptidyl peptidase-4 (DPP-4) is an aminopeptidase that inhibits the enzymatic degradation of glucagon-like peptide-1, glucose-dependent insulinotropic polypeptides, neuropeptides, and various chemokines. Recent studies reported that serum DPP-4 concentration is correlated with clinical parameters of obesity. However, research on these correlations has never been conducted in Korea. Therefore, we investigated the relationship between serum DPP-4 concentration and various clinical parameters of obesity in the Korean population.
Methods: Patients who visited the Health Promotion Center at Keimyung University Dongsan Medical Center for a regular medical examination between January 2013 and March 2013 and consented to participate in this study were included. We measured and analyzed parameters of obesity. In addition, serum DPP-4 concentration was determined using an enzyme-linked immunosorbent assay kit.
Results: Serum DPP-4 concentration was positively correlated with lean body mass, total cholesterol level, and creatinine level. Serum DPP-4 concentration was higher in the obese group than in the normal body mass index (BMI) group. No significant difference in serum DPP-4 concentration was found between the metabolically healthy group and metabolically unhealthy group.
Conclusion: Serum DPP-4 concentration was higher in the obesity group than in the normal BMI group, which was associated with obesity-related factors.
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KEYWORD
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Dipeptidyl peptidase-4, Obesity, Biomarker
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